Preheat oven to 350 degrees F (180 degrees C). Coat two 9x5 loaf pans with cooking spray and set aside. Place halves of the Refrigerated Biscuits (16) on a flat work surface.
In a large bowl, combine the Granulated Sugar (1 cup), Canned Pumpkin Pie Mix (1 cup), Pumpkin Pie Spice (1 teaspoon) and Butter (5 tablespoon). Stir until combined. Using a spoon, divide the mixture between the biscuits. Carefully stack 8 of the biscuits on top of each other.
Turn the stack sideways and add to one of the prepared pans (you will be adding more, so leave room). Stack 8 more biscuits, making sure the top biscuit is filling-side down (filling should not touch pan). Turn sideways and add to the same loaf pan. Spread the pieces out to fit. Repeat process with remaining loaf pan and biscuits. Bake in preheated oven for 40 minutes, or until dough is cooked through.
In a medium bowl, combine Powdered Confectioners Sugar (1 cup), Milk (1/8 cup) and Vanilla Extract (1 teaspoon). Stir until smooth. Divide the frosting between the loaves, pouring over the top.
Serve warm and enjoy!